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Following is a list of selected peer-reviewed research publications by Cytex scientists and their colleagues in the academic community.

Chondrogenic, hypertrophic, and osteochondral differentiation of human mesenchymal stem cells on three-dimensionally woven scaffolds.

Larson BL, Yu SN, Park H, Estes BT, Moutos FT, Bloomquist CJ, Wu PB, Welter JF, Langer R, Guilak F, Freed LE.  J Tissue Eng Regen Med. 2019;13(8):1453-65. Epub 2019/05/23. doi: 10.1002/term.2899. PubMed PMID: 31115161; PMCID: PMC6715532.

Chondrogenic Differentiation Processes in Human Bone-Marrow Aspirates Seeded in Three-Dimensional-Woven Poly(varepsilon-Caprolactone) Scaffolds Enhanced by Recombinant Adeno-Associated Virus-Mediated SOX9 Gene Transfer.

Venkatesan JK, Moutos FT, Rey-Rico A, Estes BT, Frisch J, Schmitt G, Madry H, Guilak F, Cucchiarini M. Hum Gene Ther. 2018;29(11):1277-86. Epub 2018/05/03. doi: 10.1089/hum.2017.165. PubMed PMID: 29717624; PMCID: PMC6247986.

Composite Cellularized Structures Created from an Interpenetrating Polymer Network Hydrogel Reinforced by a 3D Woven Scaffold.

Moffat KL, Goon K, Moutos FT, Estes BT, Oswald SJ, Zhao X, Guilak F. Macromol Biosci. 2018;18(10):e1800140. Epub 2018/07/25. doi: 10.1002/mabi.201800140. PubMed PMID: 30040175; PMCID: PMC6687075.

Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3D Woven Scaffolds.

Huynh NPT, Brunger JM, Gloss CC, Moutos FT, Gersbach CA, Guilak F. Tissue Eng Part A. 2018;24(19-20):1531-44. Epub 2018/05/15. doi: 10.1089/ten.TEA.2017.0510. PubMed PMID: 29756533; PMCID: PMC6198766.

Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs.

Brunger JM, Zutshi A, Willard VP, Gersbach CA, Guilak F. Stem Cell Reports. 2017 May 9;8(5):1202-1213. doi: 10.1016/j.stemcr.2017.03.022. Epub 2017 Apr 27. PMID: 28457885. Free PMC Article

CRISPR/Cas9 Editing of Murine Induced Pluripotent Stem Cells for Engineering Inflammation-Resistant Tissues.

Brunger JM, Zutshi A, Willard VP, Gersbach CA, Guilak F. Arthritis Rheumatol. 2017 May;69(5):1111-1121. doi: 10.1002/art.39982. Epub 2017 Mar 31. PMID: 27813286. Abstract

Functional Outcome Measures in a Surgical Model of Hip Osteoarthritis in Dogs.

Little D, Johnson S, Hash J, Olson SA, Estes BT, Moutos FT, Lascelles BD, Guilak F. J Exp Orthop. 2016 Dec;3(1):17., doi: 10.1186/s40634-016-0053-5. Epub 2016 Aug 15. PMID: 27525982. Free PMC Article

Anatomically Shaped Tissue-Engineered Cartilage with Tunable and Inducible Anticytokine Delivery for Biological Joint Resurfacing.

Moutos FT, Glass KA, Compton SA, Ross AK, Gersbach CA, Guilak F, Estes BT. Proceedings of the National Academy of Sciences, 2016 July 18, doi: 10.1073/pnas.1601639113.  Abstract

Tissue Engineering: Composite Three-Dimensional Woven Scaffolds with Interpenetrating Network Hydrogels to Create Functional Synthetic Articular Cartilage.

Liao IC, Moutos FT, Estes BT, Zhao X, Guilak F. Advanced Functional Materials. 2013 December 13;47/2013:5825. doi: 10.1002/adfm.201370250

Genipin-Crosslinked Cartilage-Derived Matrix as a Scaffold for Human Adipose-Derived Stem Cell Chondrogenesis.

Cheng NC, Estes BT, Young TH, Guilak F. Tissue Eng Part A. 2013 Feb;19(3-4):484-96. doi: 10.1089/ten.TEA.2012.0384. Epub 2012 Nov 30.  PMID: 23088537 [PubMed – indexed for MEDLINE]

The Inhibition by Interleukin 1 of MSC Chondrogenesis and the Development of Biomechanical Properties in Biomimetic 3D Woven PCL Scaffolds.  

Ousema PH, Moutos FT, Estes BT, Caplan AI, Lennon DP, Guilak F, Weinberg JB. Biomaterials. 2012 Dec;33(35):8967-74. doi: 10.1016/j.biomaterials.2012.08.045. Epub 2012 Sep 19.  PMID: 22999467 [PubMed – indexed for MEDLINE]

Three-Dimensional Culture Systems to Induce Chondrogenesis of Adipose-Derived Stem Cells.

Estes BT, Guilak F.  Methods Mol Biol. 2011;702:201-17. doi: 10.1007/978-1-61737-960-4_15. PMID: 21082404 [PubMed – indexed for MEDLINE]  Free PMC Article

Multifunctional Hybrid Three-Dimensionally Woven Scaffolds for Cartilage Tissue Engineering.

Moutos FT, Estes BT, Guilak F.  Macromol Biosci. 2010 Nov 10;10(11):1355-64. doi: 10.1002/mabi.201000124. PMID: 20857388 [PubMed – indexed for MEDLINE]  Free PMC Article

Isolation of Adipose-Derived Stem Cells and their Induction to a Chondrogenic Phenotype.

Estes BT, Diekman BO, Gimble JM, Guilak F.  Nat Protoc. 2010 Jul;5(7):1294-311. doi: 10.1038/nprot.2010.81. Epub 2010 Jun 17. PMID: 20595958 [PubMed – indexed for MEDLINE] Free PMC Article

2010 Nicolas Andry Award: Multipotent Adult Stem Cells from Adipose Tissue for Musculoskeletal Tissue Engineering.

Guilak F, Estes BT, Diekman BO, Moutos FT, Gimble JM. Clin Orthop Relat Res. 2010 Sep;468(9):2530-40. doi: 10.1007/s11999-010-1410-9. Epub 2010 Jul 13. Review. PMID: 20625952 [PubMed – indexed for MEDLINE] Free PMC Article

Advanced Material Strategies for Tissue Engineering Scaffolds.

Freed LE, Engelmayr GC Jr, Borenstein JT, Moutos FT, Guilak F. Adv Mater. 2009 Sep 4;21(32-33):3410-8. doi: 0.1002/adma.200900303. No abstract available. PMID: 20882506 [PubMed] Free PMC Article

In Vitro Generation of Mechanically Functional Cartilage Grafts Based on Adult Human Stem Cells and 3D-Woven Poly(Epsilon-Caprolactone) Scaffolds.

Valonen PK, Moutos FT, Kusanagi A, Moretti MG, Diekman BO, Welter JF, Caplan AI, Guilak F, Freed LE. Biomaterials. 2010 Mar;31(8):2193-200. doi: 10.1016/j.biomaterials.2009.11.092. Epub 2010 Jan 19. PMID: 20034665 [PubMed – indexed for MEDLINE] Free PMC Article

Functional Properties of Cell-Seeded Three-Dimensionally Woven Poly(Epsilon-Caprolactone) Scaffolds for Cartilage Tissue Engineering.

Moutos FT, Guilak F. Tissue Eng Part A. 2010 Apr;16(4):1291-301. doi: 10.1089/ten.TEA.2009.0480.
PMID: 19903085 [PubMed – indexed for MEDLINE] Free PMC Article